THE NICK LAB HOME PAGE

Gene Regulation

Gene Therapy

Harry S. Nick, Ph.D. University of Pennsylvania

TITLE: Professor

MAILING ADDRESS:
Department of Neuroscience
College of Medicine, University of Florida
Box 100244 JHMHC
Gainesville, FL 32610

PHONE #s: OFF: (352) 392-3303
FAX: (352) 392-6511

LAB: (352) 392-9239

EMAIL: hnick@ufl.edu

CURRICULUM VITAE: Dr. Harry S. Nick

Overall Research Goals:

Our laboratory is interested in understanding the molecular mechanisms

that control tissue specific gene regulation and in targeting the expression

of cytoprotective proteins through gene therapy strategies. Research has

focused on proteins that exhibit both pro- and anti-inflammatory activities

in the lung, intestine and brain. These genes include manganese superoxide

dismutase (MnSOD), a potent cyto protective anti-oxidant protein,

the inducible nitric oxide synthase (iNOS) gene which generates

elevated levels of the powerful neurotransmitter and vasodilator,

nitric oxide (NO) and cytoplasmic phospholipase A₂ (cPLA₂) which

controls intracellular levels of arachidonate metabolites. These genes

are also linked through transcriptional regulation by a subset of

pro-inflammatory mediators, including bacterial endotoxin (LPS),

interleukin 1 (IL-1), tumor necrosis factor (TNF-a) and interferon-g.

To read a description of our research on:

· Manganese Superoxide Dismutase (MnSOD) click here

· MnSOD Chromatin Structure click here

· In vivo Footprinting of MnSOD Promoter click here

· Identification of an Intronic Enhancer click here

· MnSOD mRNA Destabilizing Element click here

· Regulation of the inducible nitric oxide synthase click here

· Regulation of human cytosolic phospholipase A₂ click here

· Gene Therapy for Type I Diabetes click here

To see a list of the students trained in this lab click here

To read a description of our collaborators click here

Click on one of these links to go to the site:

University of Florida

Department of Neuroscience

Evelyn F. and William L. McKnight Brain Institute at the University of Florida

The University of Florida College of Medicine

University of Florida Athletic Association

PEDRO'S BIOMEDICAL RESEARCH TOOLS

NIH HOMEPAGE

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Send questions about science to hnick@ufl.edu